nav1.7 inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12184	Nav1.7 inhibitor		Others
	Nav1.7 inhibitor is a potent inhibitor of Nav1.7.		Others
T12181	NaV1.7 inhibitor-1		Sodium Channel
	NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).		Sodium Channel
T8711	PF-05186462	PF-05150122	Sodium Channel
	PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.		Sodium Channel
T2173	Veratridine		Sodium Channel
	Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.		Sodium Channel
T9461	AZ194		Sodium Channel
	CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.		Sodium Channel
T9647	GX 201	GX-201	Sodium Channel
	GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.		Sodium Channel
T7336	ICA-121431	2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl	Sodium Channel
	ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.		Sodium Channel
TQ0014	GNE-131		Sodium Channel
	GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).		Sodium Channel
T9685	DS-1971a		Sodium Channel
	DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.		Sodium Channel
T15358	Funapide	TV 45070,XEN402	Sodium Channel
	Funapide (TV 45070) is a potent Sodium Channel Nav1.7 inhibitor with potential anti-inflammatory activity for the treatment of erythema gangrenosum, musculoskeletal pain, knee osteoarthritis, and postherpetic nerves.		Sodium Channel
T23439	TC-N 1752		Sodium Channel
	TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.		Sodium Channel
T7502L	PF 05089771	PF-05089771,PF05089771	Sodium Channel
	PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.		Sodium Channel
T50030	1-(2,4-difluorophenyl)guanidine hydrochloride		Others
	1-(2,4-difluorophenyl)guanidine hydrochloride is a compound that is a potent and selective inhibitor of the voltage-gated sodium channel Nav1.7, a key player in pain signaling. It is therefore able to reduce pain signali...		Others
TN1254	3'-Methoxydaidzein		Sodium Channel
	3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla...		Sodium Channel
T27520	GX-395	GX 395
	GX-395 is a novel Nav1.7 inhibitor.
T12180	Nav1.7-IN-6		Others
	Nav1.7-IN-6, a selective inhibitor of Nav1.7.		Others
T12183	Nav1.7-IN-3		Others
	Nav1.7-IN-3 is a selective and orally bioavailable inhibitor of voltage-gated sodium channel Nav1.7(IC50 of 8 nM).		Others
T28371	PF-06456384	PF 6456384,PF06456384,PF6456384,PF 06456384,PF-6456384
	PF-06456384 is a highly potent and selective NaV1.7 inhibitor with IC50 value of 0.01 nM.
T33943	PF-04856264	PF-4856264,PF4856264,PF 4856264
	PF-04856264 is a potent and selective human Nav1.7 voltage-gated sodium channel inhibitor (IC50 = 28 nM).
T27521	GX-936	GX 936,PF 05196233,PF05196233,GX936,PF-05196233
	GX-936, a Nav1.7 inhibitor, inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel.